Lab Experiment

SERVICES

IDBR OFFERS THE FOLLOWING SERVICES TO COMPANIES AND INSTITUTIONS ON A FEE FOR SERVICE BASIS

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Analytical Method development

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In-vitro Release Test (IVRT)- Oral and topical dosage forms

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Formulation Development

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In vitro Permeability Test- Skin, nail and mucous membranes

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Stability studies

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Physicochemical characterization of APIs and excipients

ANIMAL STUDIES

  • Skin sensitivity studies

  • Plasma pharmacokinetic studies in animal models

  • CNS pharmacokinetics of drugs

  • Skin pharmacokinetics of drugs

  • Nail pharmacokinetics of drugs

  • Pharmacodynamic studies in animal models

    • Anti-diabetic activity

    • Treatment of Hypetrophic Scars

    • Treatment of acute and chronic wounds

    • Skin hydration

    • Anti inflammatory activity

    • Collagen production/denaturation assays

    • Antioxidant property

  • Bioavailability/Bioequivalence in animal models

CELL CULTURE

  • Cell viability assays

  • Anticancerous activities

  • ELISA

DMPK SERVICES

PHYSICOCHEMICAL PROPERTIES

  • Solubility (Thermodynamic and Kinetic method) In buffers of Various pH (PBS, FASSIF, FESSIF, FESGF, FASGF or any assay buffers)

  • Simultaneous determination of Log P, Log D and pKa

  • Chemical Stability

  • Blood Partitioning

ANIMAL PHARMACOKINETICS

  • Pharmacokinetics by various routes viz., oral, intravenous, intra-peritoneal, subcutaneous in mice and rats.

  • Tissue Distribution

  • Mass Balance

IN VITRO PERMEABILITY

  • PAMPA

  • MDR1-MDCK

  • Caco-2

  • Skin

  • Nail

  • Mucous Membrane

PROTEIN BINDING

  • Plasma Protein Binding (ultra Filtration and Equilibrium Dialysis)

  • Microsomal Protein Binding

IN VITRO METABOLISM

  • Metabolic Stability , Liver Microsomes , S-9 Fraction , Cryopreserved Hepatocyte .

  • Cytochrome P450 Inhibition

  • Plasma Stability

INSTITUTE FOR DRUG DELIVERY & BIOMEDICAL RESEARCH

Telephone : 91-984-557-7103

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